Details
Reliable factory customized supply Moroxydine hydrochloride 3160-91-6
- Molecular Formula: C6H13N5O*ClH
- Molecular Weight: 207.663
- Appearance/Colour: white crystalline powder
- Vapor Pressure: 0.000207mmHg at 25°C
- Melting Point: 211-214 °C(lit.)
- Boiling Point: 327 °C at 760 mmHg
- Flash Point: 151.6 °C
- PSA： 98.22000
- LogP: 0.76700
Moroxydine hydrochloride(Cas 3160-91-6) Usage
|
Manufacturing Process |
43.5 g morpholine, 41.7 ml concentrated hydrochloric acid, 40 ml of water, and 42 g dicyandiamide are refluxed for 48 hours, whereupon the reaction mixture is cooled to +5°C and filtered. The filtrate is evaporated to dryness and extracted and extracted with boiling ethanol. Yield: 50 g. The formed 4- morpholinecarboximidoylguanidine hydrochloride is purified by recrystallization from methanol. The salt may be converted into the base by adding equivalent of any basic compound (triethylamine, sodium bicarbonate and so on).In practice it is usually used as hydrochloride. |
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Therapeutic Function |
Antiviral |
|
General Description |
Determination of moroxydine hydrochloride in Gan Mao Qing capsules by derivative spectrophotometric signal multiplier method has been reported. Therapeutical efficiency of moroxidine hydrochloride against herpes virus induced keratoconjunctivitis has been evaluated by immunofluorescence techniques. |
InChI:InChI=1/C6H13N5O.ClH/c7-5(8)10-6(9)11-1-3-12-4-2-11;/h1-4H2,(H5,7,8,9,10);1H
3160-91-6 Relevant articles
Synthesis method and application of morpholine guanidine hydrochloride
-
Paragraph 0024-0030, (2019/08/20)
The invention relates to the field of or...
Hybrid molecules composed of 2,4-diamino-1,3,5-triazines and 2-imino-coumarins and coumarins. Synthesis and cytotoxic properties
Makowska, Anna,Saczewski, Franciszek,Bednarski, Patrick J.,Saczewski, Jaros?aw,Balewski, ?ukasz
, (2018/07/13)
A series of 2-imino-2H-chromen-3-yl-1,3,...
BIGUANIDE COMPOUND AND USE THEREOF
-
Paragraph 0246; 0247; 0266; 0267, (2017/10/07)
The present invention relates to a guani...
Synthetic method of moroxydine hydrochlofide
-
Paragraph 0039; 0040, (2016/10/10)
The invention discloses a synthetic meth...
3160-91-6 Process route
-
-
110-91-8,99108-56-2
morpholine
-
-
127099-85-8,780722-26-1,461-58-5
N-Cyanoguanidine
-
-
3160-91-6,7420-18-0
moroxydine hydrochloride
| Conditions | Yield |
|---|---|
|
morpholine;
With
hydrogenchloride;
In
water;
at 19 ℃;
pH=1 - 2;
N-Cyanoguanidine;
In
i-Amyl alcohol;
at 135 ℃;
Temperature;
Solvent;
|
85%
|
|
In
1,4-dioxane;
at 90 ℃;
for 0.25h;
Microwave irradiation;
|
-
-
127099-85-8,780722-26-1,461-58-5
N-Cyanoguanidine
-
-
111-46-6
diethylene glycol
-
-
3160-91-6,7420-18-0
moroxydine hydrochloride
| Conditions | Yield |
|---|---|
|
With
sulfuric acid; ammonium chloride;
In
water;
at 120 ℃;
for 1h;
under 2250.23 Torr;
Pressure;
Temperature;
Sealed tube;
Large scale;
|
5.2 kg
|
3160-91-6 Upstream products
-
10024-89-2
morpholin hydrochloride
-
127099-85-8
N-Cyanoguanidine
-
110-91-8
morpholine
-
111-46-6
diethylene glycol
3160-91-6 Downstream products
-
30072-42-5
4-morpholin-4-yl-6-styryl-[1,3,5]triazin-2-ylamine
-
29936-00-3
6-(2-ethyl-benzofuran-3-yl)-4-morpholin-4-yl-1(5) ,6-dihydro-[1,3,5]triazin-2-ylamine
-
29936-01-4
N -[4-ethyl-5-(2-hydroxy-phenyl)-pyrimidin-2-yl]-morpholine-4-carboximidic acid amide
-
29936-02-5
N -[4-ethyl-5-(2-hydroxy-phenyl)-6-methyl-pyrimidin-2-yl]-morpholine-4-carboximidic acid amide
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