Details
Factory Sells Best Quality 4-Iodopyrazole 3469-69-0 with USP
- Molecular Formula: C3H3IN2
- Molecular Weight: 193.975
- Appearance/Colour: off-white crystalline powder
- Vapor Pressure: 0.003mmHg at 25°C
- Melting Point: 108-110 °C(lit.)
- Refractive Index: 1.688
- Boiling Point: 291.886 °C at 760 mmHg
- PKA: 12.99±0.50(Predicted)
- Flash Point: 130.328 °C
- PSA： 28.68000
- Density: 2.336 g/cm3
- LogP: 1.01430
4-Iodopyrazole(Cas 3469-69-0) Usage
|
General Description |
4-Iodopyrazole is a valuable intermediate for the synthesis of biologically active compounds. It undergoes iodination in the presence of iodine and ammonium hydroxide to yield 3,4-di-iodo- and 3,4,5-tri-iodo-pyrazole. |
InChI:InChI=1/C3H3IN2/c4-3-1-5-6-2-3/h1-2H,(H,5,6)
3469-69-0 Relevant articles
4-Phosphopyrazol-2-yl alanine: A non-hydrolysable analogue of phosphohistidine
Lilley, Matthew,Mambwe, Bezaleel,Thompson, Mark J.,Jackson, Richard F. W.,Muimo, Richmond
, p. 7305 - 7308 (2015)
We report the synthesis of a stable anal...
Improved synthesis of 1H-pyrazole-4-carbaldehyde
Taydakov, Ilya V.,Krasnoselskiy, Sergey S.,Dutova, Tatiana Y.
, p. 2430 - 2434 (2011)
A simple and convenient two-step method ...
Cytotoxic Ruthenium(II) Complexes of Pyrazolylbenzimidazole Ligands That Inhibit VEGFR2 Phosphorylation
Acharya, Moulinath,Chakraborty, Ayan,Chakraborty, Manas Pratim,Das, Rahul,Koley, Tuhin Subhra,Mukherjee, Arindam,Purkait, Kallol,Roy, Shantanu Saha,Roy, Souryadip
supporting information, p. 18379 - 18394 (2021/12/01)
Eight new ruthenium(II) complexes of N,N...
Cui-catalyzed coupling reactions of 4-iodopyrazoles and alcohols: Application toward withasomnine and Homologs
Harusawa, Shinya,Hayama, Noboru,Kubo, Yumika,Kuroiwa, Nao,Nakamizu, Ayaka,Nishikawa, Kohei,Ono, Jun,Takagaki, Toshiki,Tatsui, Yuya,Usami, Yoshihide,Yoneyama, Hiroki
, (2021/06/21)
The direct 4-alkoxylation of 4-iodo-1H-p...
Method for synthesizing 1 - methyl -4 -iodo pyrazole (by machine translation)
-
Paragraph 0050-0053, (2020/06/16)
The invention relates to the technical f...
PROCESSES AND INTERMEDIATES FOR MAKING A JAK INHIBITOR
-
Paragraph 0116-0117, (2019/08/22)
This invention relates to processes and ...
3469-69-0 Process route
-
-
288-13-1
NH-pyrazole
-
-
3469-69-0
4-iodopyrazole
| Conditions | Yield |
|---|---|
|
With
ammonium cerium(IV) nitrate; iodine;
In
acetonitrile;
at 20 ℃;
for 3h;
|
98%
|
|
With
sulfuric acid; iodine; iodic acid;
In
acetic acid;
at 70 ℃;
for 0.25h;
|
97.5%
|
|
With
ammonium cerium(IV) nitrate; iodine;
In
acetonitrile;
at 20 ℃;
for 3h;
|
97%
|
|
With
ammonium cerium (IV) nitrate; iodine;
In
acetonitrile;
at 27 ℃;
for 8h;
|
97%
|
|
With
K(1+)*Cl2I(1-);
In
water;
at 20 ℃;
for 6h;
|
95%
|
|
With
potassium iodate; sulfuric acid; iodine;
In
chloroform; water;
at 50 ℃;
for 3h;
|
93%
|
|
With
ammonium cerium(IV) nitrate; iodine;
In
acetonitrile;
at 20 ℃;
for 2.5h;
|
91%
|
|
With
ammonium cerium (IV) nitrate;
|
91%
|
|
With
dihydrogen peroxide; iodine;
In
water;
at 20 ℃;
|
90%
|
|
With
ethanol; dihydrogen peroxide; iodine;
at 70 ℃;
for 1h;
|
90%
|
|
NH-pyrazole;
With
sulfuric acid; iodine; iodic acid;
In
acetic acid;
at 60 ℃;
With
sodium hydrogencarbonate; sodium carbonate;
In
acetic acid;
|
89%
|
|
With
sulfuric acid; iodine; iodic acid; acetic acid;
at 60 ℃;
for 1.75h;
|
89%
|
|
With
iodine; n-butyltriphenylphosphonium peroxodisulfate;
In
water; acetonitrile;
at 20 ℃;
for 2h;
Reagent/catalyst;
regioselective reaction;
|
89%
|
|
With
sulfuric acid; iodic acid; acetic acid;
at 60 ℃;
for 1h;
|
88%
|
|
With
N-iodo-succinimide;
In
tetrahydrofuran;
at 10 - 20 ℃;
Inert atmosphere;
|
88.6%
|
|
With
N-iodo-succinimide;
In
tetrahydrofuran;
at 10 - 20 ℃;
for 1h;
|
88.6%
|
|
With
N-iodo-succinimide;
In
tetrahydrofuran; water;
at 10 - 20 ℃;
Large scale;
|
88.6%
|
|
With
sulfuric acid; iodic acid dihydrate; iodine; acetic acid;
In
water;
at 60 - 65 ℃;
for 4h;
|
86%
|
|
With
sodium hydroxide; Rodapon N 50; iodine;
In
water;
at 20 ℃;
for 0.25h;
|
85%
|
|
With
dihydrogen peroxide; iodine;
In
water;
at 20 ℃;
|
85%
|
|
With
dihydrogen peroxide; iodine;
In
water;
|
85.6%
|
|
With
iodine; periodic acid;
In
ethanol;
for 0.116667h;
microwave irradiation;
|
77%
|
|
NH-pyrazole;
With
sodium acetate;
In
water;
at 60 ℃;
With
dihydrogen peroxide; iodine; potassium iodide;
In
water;
for 6h;
Reflux;
|
74%
|
|
With
1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione; sulfuric acid; potassium iodide;
In
water;
at 0 ℃;
for 0.0166667h;
|
73%
|
|
With
dihydrogen peroxide; iodine;
In
water;
at 20 ℃;
for 24h;
|
63%
|
|
With
Iodine monochloride;
In
ethyl acetate;
at 25 - 30 ℃;
for 24h;
Irradiation;
|
61%
|
|
With
sodium nitrate; sodium hydrogencarbonate; potassium iodide;
In
chloroform; water;
at 30 ℃;
Electrolysis;
|
57%
|
|
With
sulfuric acid; silica gel; periodic acid; sodium chloride;
In
water;
at 25 ℃;
for 0.25h;
|
55%
|
|
With
dihydrogen peroxide; iodine;
In
water;
|
54%
|
|
With
bismuth(III) nitrate; iodine; silica gel;
at 20 ℃;
for 0.166667h;
|
52%
|
|
With
lead(II,IV) oxide; iodine; acetic anhydride; acetic acid;
at 45 - 50 ℃;
for 0.25h;
|
24%
|
|
With
water; iodine; sodium acetate; potassium iodide;
|
|
|
With
ammonium cerium (IV) nitrate; iodine;
In
acetonitrile;
|
|
|
With
dihydrogen peroxide; iodine;
In
water;
|
|
|
With
potassium iodate; sulfuric acid; potassium iodide;
In
chloroform; water;
at 50 ℃;
for 2h;
Temperature;
Time;
|
96.8 %Spectr.
|
|
With
ammonium cerium (IV) nitrate; iodine;
In
acetonitrile;
|
-
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2075-45-8
4-bromo-1H-pyrazole
-
-
3469-69-0
4-iodopyrazole
| Conditions | Yield |
|---|---|
|
With
copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium iodide;
In
1,4-dioxane; water;
at 180 ℃;
for 0.5h;
under 9050.33 Torr;
Flow reactor;
Inert atmosphere;
|
75%
|
3469-69-0 Upstream products
-
288-13-1
NH-pyrazole
-
28466-26-4
4-aminopyrazole
-
2075-45-8
4-bromo-1H-pyrazole
3469-69-0 Downstream products
-
98027-52-2
1-(4-iodo-1H-pyrazol-1-yl)ethanone
-
116228-38-7
1-Benzoyl-4-jodpyrazol
-
145243-92-1
4-iodo-1-(methoxymethyl)-1H-pyrazole
-
116228-40-1
4-iodo-1-[(4-methylphenyl)sulfonyl]-1H-pyrazole
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