rifamide

  • Name: rifamide
  • CAS: 2750-76-7
  • Purity: 99%
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Details

Excellent chemical plant bulk supply rifamide 2750-76-7

  • Molecular Formula: C43H58 N2 O13
  • Molecular Weight: 810.939
  • Vapor Pressure: 0mmHg at 25°C 
  • Melting Point: 170°C (rough estimate) 
  • Refractive Index: 1.4670 (estimate) 
  • Boiling Point: 927.4°Cat760mmHg 
  • Flash Point: 514.7°C 
  • PSA： 210.62000 
  • Density: 1.3g/cm3 
  • LogP: 5.43370 

rifamide(Cas 2750-76-7) Usage

Pharmaceutical Applications

The diethyl amide of rifamycin B, formulated as the sodium salt for parenteral administration. It exhibits high activity against Gram-positive organisms and M. tuberculosis typical of the group. MICs for Gram-negative bacilli are of the order of 20–50 mg/L.It is absorbed orally and is rapidly eliminated through the bile, achieving concentrations sufficient to inhibit Gramnegative bacilli. In contrast to rifampicin, it can be administered as the sodium salt by intramuscular injection. A dose of 150 mg produces mean plasma levels of about 1 mg/L. The plasma halflife is about 2 h. The same dosage produces concentrations over 1 g/L in bile and c. 40 mg/L in the gallbladder wall.Toxicity and side effects are similar to those of other rifamycins. It has been used in staphylococcal infections and infections of the biliary tract. It is unsuitable for the treatment of tuberculosis because of insufficient distribution to the tissues.

InChI:InChI=1/C43H58N2O13/c1-12-45(13-2)31(47)20-55-30-19-28-38(51)33-32(30)34-40(26(8)37(33)50)58-43(10,41(34)52)56-18-17-29(54-11)23(5)39(57-27(9)46)25(7)36(49)24(6)35(48)21(3)15-14-16-22(4)42(53)44-28/h14-19,21,23-25,29,35-36,39,48-51H,12-13,20H2,1-11H3,(H,44,53)/b15-14+,18-17+,22-16+/t21-,23-,24+,25-,29-,35-,36+,39+,43-/m0/s1

2750-76-7 Process route

Rifamycin B
13929-35-6

Rifamycin B

diethylamine
109-89-7

diethylamine

Rifocin-M
2750-76-7

Rifocin-M

Conditions
Conditions Yield
With dicyclohexyl-carbodiimide; In tetrahydrofuran;

2750-76-7 Upstream products

  • 13929-35-6
    13929-35-6

    Rifamycin B

  • 109-89-7
    109-89-7

    diethylamine

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